South San Francisco Hotels

your current months are December, 2024 and January, 2025.
December 2024
January 2025

Find and book your perfect stay

Earn rewards on every night you stay
Save more with Member Prices
Free cancellation options if plans change

Where to stay in South San Francisco?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in South San Francisco

Top landmarks in South San Francisco

Frequently asked questions

Can I book a refundable accommodation option in South San Francisco?
If you want the flexibility to change your plans to South San Francisco, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in South San Francisco if I want a holiday rental instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 60 holiday homes. In addition, you can choose from 12 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August, with an average temperature of 17°C. February and January are the chilliest months, when the average temperature is 11°C. The rainiest months are December and January.
Why should I book my South San Francisco hotel with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.