Cayo Santa Maria Hotels

Free cancellation options if plans change
Earn rewards on every night you stay
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Check prices for these dates

Tonight
20 Feb - 21 Feb
Tomorrow
21 Feb - 22 Feb
This weekend
21 Feb - 23 Feb
Next weekend
28 Feb - 2 Mar

Where to stay in Cayo Santa Maria?

Learn more about Cayo Santa Maria

If you're wanting to unwind at the beach, look no further than Playa Las Gaviotas in the area.

See all hotels in Cayo Santa Maria

Frequently asked questions

Can I book a refundable accommodation option in Cayo Santa Maria?
If you want the flexibility to change your plans to Cayo Santa Maria, most hotels offer refundable* rates that you can book. You can see this accommodation by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Cayo Santa Maria be like during my visit?
With an average temperature of 24°C during the coldest months, Cayo Santa Maria is a great place to visit at any time of year.
Why should I book my Cayo Santa Maria hotel with Hotels.com?
There are lots of reasons to book your Cayo Santa Maria trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.