Seneca Hotels

October 2026
November 2026

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Check prices for these dates

Next weekend
25 Sept - 27 Sept
In two weeks
2 Oct - 4 Oct

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on 19 September 2026.

1. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$114
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

2. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$136
includes taxes & fees
22 Sept - 23 Sept
Best Western Seneca-Clemson

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$148
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson

4. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$181
includes taxes & fees
28 Sept - 29 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

5. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$170
includes taxes & fees
27 Sept - 28 Sept
Hampton Inn & Suites Seneca-Clemson Area

6. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
includes taxes & fees
20 Sept - 21 Sept
Lakeside Lodge Clemson

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$112
includes taxes & fees
20 Sept - 21 Sept
Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$187
includes taxes & fees
19 Oct - 20 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Seneca
S$1,001
includes taxes & fees
27 Sept - 28 Sept
Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

10. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
S$158
includes taxes & fees
20 Sept - 21 Sept
Clemson University's James F. Martin Inn

11. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
S$150
includes taxes & fees
27 Sept - 28 Sept
Hampton Inn Clemson-University Area

12. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
S$154
includes taxes & fees
18 Oct - 19 Oct
Comfort Inn & Suites Clemson - University Area

13. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
S$217
includes taxes & fees
19 Oct - 20 Oct
The Abernathy of Clemson

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
S$155
includes taxes & fees
21 Sept - 22 Sept
Best Western Plus Clemson Hotel & Conference Center

15. Inn @ Clemson

Inn @ Clemson
Clemson
S$113
includes taxes & fees
23 Sept - 24 Sept
Inn @ Clemson

16. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
S$183
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express & Suites Clemson by IHG

17. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
S$115
includes taxes & fees
25 Sept - 26 Sept
Rodeway Inn & Suites Walhalla

18. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
S$190
includes taxes & fees
27 Sept - 28 Sept
Courtyard Marriott Clemson

19. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
S$325
includes taxes & fees
28 Sept - 29 Sept
The Shepherd Hotel Downtown Clemson

20. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
S$211
includes taxes & fees
27 Sept - 28 Sept
The Inn at Patrick Square
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$292
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$425
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$700
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$700
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$772
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$220
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$401
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$700
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$700
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$814
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$359
for 2 nights, 1 room
S$180 per night
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$389
for 2 nights, 1 room
S$195 per night
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$243
for 2 nights, 1 room
S$122 per night
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$320
for 2 nights, 1 room
S$160 per night
includes taxes & fees
Best Western Seneca-Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$365
for 2 nights, 1 room
S$182 per night
includes taxes & fees
Tru by Hilton Seneca Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$375
for 2 nights, 1 room
S$187 per night
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$271
for 2 nights, 1 room
S$135 per night
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$671
for 2 nights, 1 cabin
S$335 per night
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

8 Mi to Clemson: Peaceful Family Home w/ Yard

8 Mi to Clemson: Peaceful Family Home w/ Yard
Seneca
S$783
for 2 nights, 1 cottage
S$391 per night
includes taxes & fees
8 Mi to Clemson: Peaceful Family Home w/ Yard

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
S$899
for 2 nights, 1 cottage
S$449 per night
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Condo on Lake Hartwell 3 Mi to Clemson Stadium

Condo on Lake Hartwell 3 Mi to Clemson Stadium
Seneca
S$955
for 2 nights, 1 apartment
S$477 per night
includes taxes & fees
Condo on Lake Hartwell 3 Mi to Clemson Stadium

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
S$1,066
for 2 nights, 1 apartment
S$533 per night
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Seneca
S$809
for 2 nights, 1 cottage
S$404 per night
includes taxes & fees
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Clemson Weekends 3 Mi From Memorial Stadium

Clemson Weekends 3 Mi From Memorial Stadium
Seneca
S$1,136
for 2 nights, 1 apartment
S$568 per night
includes taxes & fees
Clemson Weekends 3 Mi From Memorial Stadium

Lakefront Fun Near Clemson! Retreat w/ Pool Access

Lakefront Fun Near Clemson! Retreat w/ Pool Access
Seneca
S$1,339
for 2 nights, 1 cottage
S$669 per night
includes taxes & fees
Lakefront Fun Near Clemson! Retreat w/ Pool Access

Check out pet-friendly hotels in Seneca

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$114
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$148
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$112
includes taxes & fees
20 Sept - 21 Sept
Days Inn by Wyndham Seneca / Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
includes taxes & fees
20 Sept - 21 Sept
Lakeside Lodge Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$187
includes taxes & fees
19 Oct - 20 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
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You may also like hotels with pools in Seneca

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$136
includes taxes & fees
22 Sept - 23 Sept
Best Western Seneca-Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$114
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
includes taxes & fees
20 Sept - 21 Sept
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$112
includes taxes & fees
20 Sept - 21 Sept
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$170
includes taxes & fees
27 Sept - 28 Sept
Hampton Inn & Suites Seneca-Clemson Area
View all properties

Go beyond your typical stay in Seneca

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Cabin
Cabin
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Apart­ment
Apart­ment
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Family friendly
Family friendly
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Cottage
Cottage
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Condo
Condo
Our prices for hotels in Seneca are cheapest in December

Price trends for hotels in Seneca

Pricing is based on two traveller single night rates
View properties in September

September

High 28°C / low 18°C. Sunny most days.
28°
18°
23°
12°
17°
12°
10°
13°
17°
22°
10°
26°
15°
31°
19°
32°
21°
31°
20°
Monthly weather averages (˚C)

Top neighbourhoods in Seneca

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
See properties
A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Wyndham Plaza

If you like shopping, take time out to go to Wyndham Plaza when in Seneca.
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World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A calm lake with mountains in the background.

Frequently Asked Questions

Can I book a refundable accommodation option in Seneca?

If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in Seneca if I want a holiday rental instead of a hotel?

If you want a good alternative to a hotel, browse our selection of 219 holiday homes. In addition, there are 23 apartments and 13 condos.

What will the weather in Seneca be like during my visit?

The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.

Why should I book my Seneca hotel with Hotels.com?

There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

Find out more about Seneca

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on 19 September 2026.

Keep exploring