Seneca Hotels

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Check prices for these dates

Tonight
28 Aug - 29 Aug
Tomorrow
29 Aug - 30 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Top 5 hotels in Seneca at a glance

  1. Tru by Hilton Seneca Clemson — 2.5-star hotel in Seneca. Guest rating: 9.2/10 — Wonderful.
  2. Quality Inn Seneca US-123 — 2.5-star hotel in Seneca. Guest rating: 8.0/10 — Very good.
  3. Lakeside Lodge Clemson — 2.5-star hotel in Seneca. Guest rating: 9.0/10 — Wonderful.
  4. Best Western Seneca-Clemson — 2.5-star hotel in Seneca. Guest rating: 8.4/10 — Very good.
  5. Hampton Inn & Suites Seneca-Clemson Area — 2.5-star hotel in Seneca. Guest rating: 9.2/10 — Wonderful.

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on comfort, location and traveller experience. Last updated on .

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$148
includes taxes & fees
6 Sept - 7 Sept
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$113
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$172
includes taxes & fees
30 Aug - 31 Aug
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$141
includes taxes & fees
31 Aug - 1 Sept
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$166
includes taxes & fees
3 Sept - 4 Sept
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$168
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$113
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$185
includes taxes & fees
7 Sept - 8 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
S$210
includes taxes & fees
2 Sept - 3 Sept
Clemson University's James F. Martin Inn

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
S$149
includes taxes & fees
6 Sept - 7 Sept
Hampton Inn Clemson-University Area

Inn @ Clemson

Inn @ Clemson
Clemson
S$107
includes taxes & fees
29 Aug - 30 Aug
Inn @ Clemson

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
S$149
includes taxes & fees
27 Sept - 28 Sept
Comfort Inn & Suites Clemson - University Area

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
S$215
includes taxes & fees
2 Sept - 3 Sept
The Abernathy of Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
S$143
includes taxes & fees
6 Sept - 7 Sept
Best Western Plus Clemson Hotel & Conference Center

Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
Clemson
S$113
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Clemson

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
S$108
includes taxes & fees
27 Sept - 28 Sept
Rodeway Inn & Suites Walhalla

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
S$155
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Clemson by IHG

Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
S$167
includes taxes & fees
6 Sept - 7 Sept
Courtyard Marriott Clemson

The Inn at Patrick Square

The Inn at Patrick Square
Clemson
S$210
includes taxes & fees
6 Sept - 7 Sept
The Inn at Patrick Square

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
S$320
includes taxes & fees
31 Aug - 1 Sept
The Shepherd Hotel Downtown Clemson
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$133
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$172
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$159
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$194
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$117
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$210
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$208
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$292
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$133
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$194
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$172
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$194
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$159
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$117
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$208
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$306
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$319
for 2 nights, 1 room
S$159 per night
includes taxes & fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$253
for 2 nights, 1 room
S$126 per night
includes taxes & fees
Quality Inn Seneca US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$361
for 2 nights, 1 room
S$181 per night
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$307
for 2 nights, 1 room
S$153 per night
includes taxes & fees
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$417
for 2 nights, 1 room
S$208 per night
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$373
for 2 nights, 1 room
S$187 per night
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$260
for 2 nights, 1 room
S$130 per night
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$90 off
S$620
for 2 nights, 1 cabin
S$310 per night
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
S$895
for 2 nights, 1 cottage
S$448 per night
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
S$1,061
for 2 nights, 1 apartment
S$531 per night
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay

Condo on Lake Hartwell 3 Mi to Clemson Stadium

Condo on Lake Hartwell 3 Mi to Clemson Stadium
Seneca
S$924
for 2 nights, 1 apartment
S$462 per night
includes taxes & fees
Condo on Lake Hartwell 3 Mi to Clemson Stadium

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
S$2,085
for 2 nights, 1 apartment
S$1,043 per night
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
S$1,361
for 2 nights, 1 apartment
S$681 per night
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$148
includes taxes & fees
6 Sept - 7 Sept
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$113
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$172
includes taxes & fees
30 Aug - 31 Aug
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$113
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$185
includes taxes & fees
7 Sept - 8 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
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You may also like hotels with pools in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$172
includes taxes & fees
30 Aug - 31 Aug
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$141
includes taxes & fees
31 Aug - 1 Sept
Best Western Seneca-Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$113
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$166
includes taxes & fees
3 Sept - 4 Sept
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$168
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$113
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in August
Typical weather for Seneca
August
High 31°C / low 20°C. Sunny most days.
View properties in August
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28°
18°
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12°
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12°
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22°
10°
26°
15°
31°
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Monthly weather averages (˚C)

Top neighbourhoods in Seneca

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Seneca City Hall

Seneca City Hall is worth a pic or two when discovering Downtown.
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Highpointe Lower Field

Highpointe Lower Field is worth a visit, located 5.7 mi (9.1 km) from central Seneca.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Convenient location. Reasonably priced. Staff is very friendly and helpful."
Kwanchanok 1-night trip
Posted 12 hours ago
Quality Inn Seneca US-123

Frequently asked questions

Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 218 holiday homes. In addition, there are 21 apartments and 12 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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