Seneca Hotels

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Check prices for these dates

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on .

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$169
includes taxes & fees
18 Oct - 19 Oct
Fairfield Inn & Suites Seneca Clemson Univ Area

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$174
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn & Suites Seneca-Clemson Area

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$149
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$142
includes taxes & fees
14 Oct - 15 Oct
Best Western Seneca-Clemson

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
includes taxes & fees
11 Oct - 12 Oct
Lakeside Lodge Clemson

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$114
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$120
includes taxes & fees
14 Oct - 15 Oct
Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$187
includes taxes & fees
20 Oct - 21 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
S$212
includes taxes & fees
11 Oct - 12 Oct
Clemson University's James F. Martin Inn

10. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
S$156
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Clemson-University Area

11. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
S$222
includes taxes & fees
19 Oct - 20 Oct
The Abernathy of Clemson

12. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
S$183
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Clemson by IHG

13. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
S$147
includes taxes & fees
18 Oct - 19 Oct
Courtyard Marriott Clemson

14. Inn @ Clemson

Inn @ Clemson
Clemson
S$109
includes taxes & fees
11 Oct - 12 Oct
Inn @ Clemson

15. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
S$276
includes taxes & fees
31 Oct - 1 Nov
The Shepherd Hotel Downtown Clemson

16. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
S$150
includes taxes & fees
13 Oct - 14 Oct
Best Western Plus Clemson Hotel & Conference Center

17. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
S$150
includes taxes & fees
1 Nov - 2 Nov
Comfort Inn & Suites Clemson - University Area

18. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
S$212
includes taxes & fees
14 Oct - 15 Oct
The Inn at Patrick Square

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
S$103
includes taxes & fees
10 Nov - 11 Nov
Rodeway Inn & Suites Walhalla

20. Clemson Memorabilia House

Clemson Memorabilia House
Clemson
S$304
includes taxes & fees
11 Oct - 12 Oct
Clemson Memorabilia House
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Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$196
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$224
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$141
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$175
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$182
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$114
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$365
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$182
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$189
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$126
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$168
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$182
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$120
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$224
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
S$561
for 2 nights, 1 room
S$280 per night
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$357
for 2 nights, 1 room
S$178 per night
includes taxes & fees
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
S$844
for 2 nights, 1 room
S$422 per night
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
S$596
for 2 nights, 1 room
S$298 per night
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$369
for 2 nights, 1 room
S$185 per night
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$128 off
S$841
for 2 nights, 1 cabin
S$420 per night
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$927
for 2 nights, 1 room
S$463 per night
includes taxes & fees
Tru by Hilton Seneca Clemson

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
S$902
for 2 nights, 1 cottage
S$451 per night
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Stunning Seneca Home w/ Lake Keowee Access!

Stunning Seneca Home w/ Lake Keowee Access!
Seneca
S$1,834
for 2 nights, 1 cottage
S$917 per night
includes taxes & fees
Stunning Seneca Home w/ Lake Keowee Access!

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
S$1,780
for 2 nights, 1 apartment
S$890 per night
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
S$1,371
for 2 nights, 1 apartment
S$686 per night
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
S$114
includes taxes & fees
18 Oct - 19 Oct
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
S$149
includes taxes & fees
18 Oct - 19 Oct
Tru by Hilton Seneca Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
S$187
includes taxes & fees
20 Oct - 21 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
S$173
includes taxes & fees
11 Oct - 12 Oct
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
S$120
includes taxes & fees
14 Oct - 15 Oct
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in October
Typical weather for Seneca
October
High 23°C / low 12°C. Sunny most days.
View properties in October
23°
12°
17°
6°
12°
4°
10°
1°
13°
3°
17°
6°
22°
10°
26°
15°
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19°
32°
21°
31°
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28°
18°
Monthly weather averages (˚C)

Top neighbourhoods in Seneca

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Highpointe Field

Highpointe Field is worth a visit, located 5.6 mi (8.9 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Toy Train Park

Toy Train Park is worth a pic or two when discovering Downtown.
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World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A sunset over a lake surrounded by dense forests and residential areas.

Check out reviews of Seneca hotels guests love

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Beautiful cabin, attentive hosts, and an overall great stay. I would definitely go back."
Sebastian 2-night trip
Posted 14 hours ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Everything was clean and just what we needed"
irene 1-night trip
Posted 18 hours ago
Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Clean rooms clean parking area nice staff all good"
Barry 1-night trip
Posted 18 hours ago
Quality Inn Seneca US-123
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

10/10 Excellent
"Convenient location for doing business in seneca, and parts of clemson. The staff was wonderful. The breakfast was great."
Lori 1-night trip
Posted 3 days ago
Fairfield Inn & Suites Seneca Clemson Univ Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"Stayed @ hotel for a football weekend. Hotel was awesome...one of the cleanest I've ever stayed in regardless of hotels' star ratings. The only reason I gave it 4 stars was two things....#1 The bed was a bit too hard for me. I'm used to softer mattresses, but these were a little too hard for me. #2....There was one staff person that was just not very friendly @ the front desk for part of my stay. She wasn't rude & she fulfilled my requests, but she just was not as outgoing as other team members & that stuck out to me. Would I stay at this hotel again? Absolutely...it's been many yrs since I've stayed in a BW...I tend to stay in the upper crust hotels, so I was very pleasantly surprised! Great job Best Western!!"
Susan 2-night trip
Posted 8 days ago
Best Western Seneca-Clemson

Frequently asked questions

Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 217 holiday homes. In addition, there are 24 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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