Cayo Guillermo Hotels

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Check prices for these dates

Tonight
14 Apr - 15 Apr
Tomorrow
15 Apr - 16 Apr
This weekend
18 Apr - 20 Apr
Next weekend
25 Apr - 27 Apr

Where to stay in Cayo Guillermo?

Top landmarks in Cayo Guillermo

Cayo Guillermo Beach

Cayo Guillermo Beach

If being by the water is a major draw, Cayo Guillermo Beach is a spot you might want to check out, located 2.1 mi (3.4 km) from central Cayo Guillermo.

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Cayo Guillermo Beach

Cayo Guillermo Marina

Cayo Guillermo Marina is worth a visit, located 2.6 mi (4.2 km) from central Cayo Guillermo.

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Cayo Guillermo Marina

Learn more about Cayo Guillermo

The region around Cayo Guillermo is home to attractions such as Cayo Guillermo Beach and Cayo Guillermo Marina.

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Frequently asked questions

Can I book a refundable accommodation option in Cayo Guillermo?
If you want the flexibility to change your plans to Cayo Guillermo, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Cayo Guillermo be like during my visit?
With an average temperature of 24°C during the coldest months, Cayo Guillermo is a great place to visit at any time of year.
Why should I book my Cayo Guillermo hotel with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.