Cayo Santa Maria Hotels

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Free cancellation

Flexible bookings on most hotels*

Where to stay in Cayo Santa Maria?

Find out more about Cayo Santa Maria

Frequently asked questions

Can I book a refundable accommodation option in Cayo Santa Maria?
If you want the flexibility to change your plans to Cayo Santa Maria, most hotels offer refundable* rates that you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Cayo Santa Maria be like during my visit?
Cayo Santa Maria is a great place to visit to enjoy the sunshine at any time of year, with an average temp of 21°C.
Why should I book my Cayo Santa Maria hotel with Hotels.com?
There are lots of reasons to book your Cayo Santa Maria trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn reward nights with our Rewards programme, saving your money.